Ryan Murelli

The Group



Course Information

Brooklyn College Chemistry Department

Ph.D. in Chemistry at CUNY Graduate Center


Murelli Research Group Publications (Brooklyn College)


15. Lu, G.; Lomonosova, E.; Cheng, X.; Moran, E. A.; Meyers, M. J.; Le Grice, S. F. J.; Thomas, C. J.; Jiang, J-K.; Meck, C.; Hirsch, D. R.; D'Erasemo, M. P.; Suyabatmaz, D. M.; Murelli, R. P.; Tavis, J. E. "Hydroxylated tropolones inhibit hepatitis B virus replication by blocking the viral ribonuclease H activity" Antimicrob. Agents Chemother. (accepted)


14. Hirsch, D. R.; Cox, G. C.; D'Erasmo, M. P.; Shakya, T.; Meck, C.; Mohd, N.; Wright, G. D.; Murelli, R. P. "Inhibition of ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones" Bioorg. Med. Chem. Lett. 2014, 24, 4943-4947. (link)



13. D'Erasmo, M. P.; Smith, W. B.; Munoz, A.; Mohandas, P.; Au, A. S.; Marineau, J.; Quadri, L. E. N.; Bradner, J. E.; Murelli, R. P. "7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-e-2-ones: Readily accessible and highly potent anticancer compounds" Bioorg. Med. Chem. Lett. 2014, 24, 4035-4038. (link)



12. Meck, C.; D' Erasmo, M. P.; Hirsch, D. R.; Murelli, R. P. "The biology and synthesis of α-hydroxytropolones" Med. Chem. Comm. 2014, 5, 842-852. (link)


11. Williams, Y. D.; Meck, C.; Mohd, N.; Murelli, R. P. "Triflic acid mediated rearrangements of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of methoxytropolones and furans" J. Org. Chem. 2013, 78, 11707-11713. (link)



10. Meck, C.; Mohd, N.; Murelli, R. P. "An oxidopyrylium cyclization/ ring-opening route to polysubstituted α-hydroxytropolones" Org. Lett. 2012, 14, 5988-5991. (link)



9. Munoz, A.; Murelli, R. P. "Acid-mediated coupling of gamma-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones" Tetrahedron Lett. 2012, 53, 6779-6781. (link)


Ryan's Postdoctoral Publications (Yale University)

8. Nelson, J. W.; Chammessian, A. G.; McEnaney, P. J.; Murelli, R. P.; Kazmiercak, B. I.; Spiegel, D. A. “A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-Native Small Molecules” ACS ChemBio, 2010, 5 , 1147-1155.(link)

See also: Cell, BioTechniques, Science Daily News and Yale Daily News

7. Zhang, A. X.; Murelli, R. P.; Barinka, C.; Michel, J.; Cocleaza, A.; Jorgensen, W. L.; Lubkowski, J.; Spiegel, D. A. “A Remote Arene Binding Site of Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules” J. Am. Chem. Soc. 2010, 132, 12711-12716.(link)

See also: Chemical & Engineering News Highlight and Nature ChemBio Highlight.

6. Murelli, R. P.; Zhang, A. X.; Michel, J.; Jorgensen, W. L.; Spiegel, D.A. “Chemical Control Over Immune Recognition:  A Class of Antibody-Recruiting Small Molecules (ARMs) that Target Prostate Cancer” J. Am. Chem. Soc. 2009, 131, 17090-17092.(link)

See also: ACS ChemBio Spotlight, ChemBioChem Highlight, Faculty of 1000 Biology Highlight, Drug Discovery News Article, Yale Daily News, and Science Daily News.

5. Stern, E.; Jay, S. M.; Demento, S. L.; Murelli, R. P.; Reed, M. A.; Malinski, T.; Spiegel, D. A.; Mooney, D. J.; Fahmy, T. M. “Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro and Nanopatterned Surfaces” Adv. Funct. Mater. 2009, 19, 2888-2895.(link)

Ryan's Graduate School Publications (Boston College)

4. Murelli, R. P.; Catalán, S.; Gannon, M. P.; Snapper, M. L. “Ruthenium-Catalyzed Enyne Cross-Metathesis-Cyclopropanation:  Three Component Access to Vinyl Cyclopropanes” Tetrahedron Lett., 2008, 49, 5714-5717.(link)

3. Murelli, R. P.; Snapper, M. L. “Ruthenium-Catalyzed Tandem Cross-Metathesis/ Wittig Olefination:  Generation of Conjugated Dienoic Esters from Terminal Olefins” Org. Lett. 2007, 9, 1749-1752.(link)

See also: Organic Chemistry Portal

2. Murelli, R. P.; Cheung, A. K.; Snapper, M. L. “Conformationally Restricted (+)-Cacospongionolide B Analogues:  Influence on Secretory Phospholipase A2 Inhibition” J. Org. Chem. 2007, 72, 1545-1552.(link)

See also: Journal Cover

1.  Cheung, A. K.; Murelli, R.; Snapper, M. L.  “Total Syntheses of (+)- and (-)-Cacospongionolide B,  Cacospongionolide E, and Related Analogues.  Preliminary Study of Structural Features Required for Phospholipase A2 Inhibition” J. Org. Chem. 2004, 69, 5712-5719.(link)

Patent Applications

1. Spiegel, D.; Murelli, R.; Zhang, A. “Chimeric Small Molecules that Recruit Antibodies to Cancer Cells” PCT Int. Appl. No. WO 2009-US2857.  Patent No. WO  2009139863. (Filed: Nov. 11, 2009).