Ryan Murelli

The Group

Research Overview

Open Positions

Course Information

Brooklyn College Chemistry Department

Ph.D. in Chemistry at CUNY Graduate Center

Research Mission

Modern medicine has been one of the major beneficiaries of advancements in the field of synthetic organic chemistry over the last several decades, and a seemingly infinite number of challenges and opportunities still exist in both fields. Our mission is to make fundamental contributions to synthetic organic chemistry, biology and medicine. To accomplish this, we seek out problems in medicinal chemistry and chemical biology that are in need of new synthetic organic chemistry developments. Thus, primary studies carried out by lab members range from reaction discovery and mechanism investigations to multi-step synthetic strategy developments. We simultaneously partner with experts in complementary fields in order to leverage these advancements in a broad range of interdisciplinary projects devoted to lead drug discovery and development.


Murelli Research Group Publications (Brooklyn College)

32. Bejcek, L. P.; Murelli, R. P. "Oxidopyrylium [5+2] Cycloaddition Chemistry: Historical Perspective and Recent Advances (2008-2018)" Tetrahedron, 2018, 74, 2501-2521. (link)

31. Tavis, J. E.; Zoidis, G.; Meyers, M. J.; Murelli, R. P. "Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H" ACS. Infect. Dis. 2018, Accepted (link)

30. D'Erasmo, M. P.; Murelli, R. P. "Fluorous-Phase Approach to α-Hydroxtropolone Synthesis" J. Org. Chem. 2018, 83, 1478-1485. (link)

29. Dehghanpir, S. D.; Birkenheuer, C. H.; Yang, K.; Murelli, R. P.; Morrison, L. A.; Le Grice, S. F. J.; Baines, J. D. "Broad Anti-Herpesviral Activity of α-Hydroxtropolones" Vet. Microbiol. 2018 214, 125-131. (link)

28. Hirsch, D. R.; Schiavone, D. V.; Berkowitz, A. J.; Morrison, L. A.; Masaoka, T.; Wilson, J. A.; Lomonosova, E.; Zhao, H.; Patel, B. S.; Dalta, S. H.; Majidi, S. J.; Pal, R.; K.; Gallicchio, E.; Tang, L.; Tavis, J. E.; Le Grice, S. F. J.; Beutler, J. A.; Murelli, R. P. "Synthesis and Biological Assessment of 3,7-Dihydroxytropolones" Org. Biomol. Chem. 2018, 16, 62-69. (link)



27. Long, K. R.; Lomonosova, E.; Li, W.; Ponzar, N. L.; Villa, J. A.; Touchette, E.; Rapp, S.; Liley, R. M.; Murelli, R. P.; Grigoryan, A.; Buller, R. M.; Wilson, L.; Bial, J.; Sagartz, J. E.; Tavis, J. E. "Efficacy of Hepatitis B Virus Ribonuclease H Inhibitors, a New Class of Replication Antagonists, in FRG Human Liver Chimeric Mice" Antiviral Res. 2018, 149, 41-47. (link)


26. Fuhr, K. N.; Hirsch, D. R.; Murelli, R. P.; Brenner-Moyer, S. E. "Catalytic Enantioselective Intermolecular [5+2] Dipolar Cycloadditions of a 3-Hydroxy-4-Pyrone-Derived Oxidopyrylium Ylide", Org. Lett., 2017, 19, 6356-9. (link)


25 Grady, L. M.; Szczepaniak, R.; Murelli, R. P.; Masaoka, T.; Le Grice, S. F. J.; Wright, D. L.; Weller, S. K. "The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus" J. Virol. 2017, 91, e01380-17 (link)


24. Lomonosova, E.; Daw, J.; Garimallaprabhakaran, A. K.; Agyemang N. A.; Ashani, Y.; Murelli, R. P.; Tavis, J. E. "Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H" Antiviral Res. 2017, 144, 164-172. (link)



23. Donlin, M. J.; Zunica, A.; Lipnicky, A; Garimallaprabhakaran, A. K.; Berkowitz, A. J.; Grigoryan, A.; Meyers, M. J.; Tavis, J. E.; Murelli, R. P. "Troponoids can inhibit growth of the human fungal pathogen Cryptococcus neoformans" Antimicrob. Agents Chemother., 2017, 61, e02574-16. (link)

Crypto SAR


22. Zhang, B.; D'Erasmo, M. P.; Murelli, R. P. Gallicchio, E. "Free Energy-Based Virtual Screening and Optimization of RNase H Inhibitors of HIV-1 Reverse Transcriptase" ACS Omega, 2016, 1, 435-47. (link)

Abstract Image


21. D'Erasmo, M. P.; Masaoka, T.; Wilson, J. A.; Hunte, E. M. Jr.; Beutler, J. A.; Le Grice, S. F. J.; Murelli, R. P. 'Traceless Solid-Phase α-Hydroxtropolone Synthesis' Med. Chem. Commun. 2016, 9, 1793-92. (link)

Solid Phase Abstract


20. Murelli, R. P.; D'Erasmo, M. P.; Hirsch, D. R.; Meck, C.; Masaoka, T.; Wilson, J. A.; Zhang, B.; Pal, R. K.; Gallicchio, E.; Beutler, J. A.; Le Grice, S. F. J. 'Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity' Med. Chem. Commun. 2016, 9, 1783-8. (link)

RNaseH Abstract


19. D'Erasmo, M. P.; Meck, C.; Lewis, C. A.; Murelli, R. P. "Discovery and Development of a 3-Component Oxidopyrylium [5+2] Cycloaddition Reaction" J. Org. Chem. 2016, 81, 3744-51. (link).


18. Ireland, P. J.; Tavis, J. E.; D'Erasmo, M. P.; Hirsch, D. R.; Murelli, R. P.; Cadiz, M. M.; Patel, B. S.; Gupta, A. K.; Edwards, T. C.; Korom, M.; Moran, E. A.; Morrison, L. A. "Synthetic α-hydroxytropolones inhibit replication of wild-type and acyclovir-resistant herpes simplex viruses" Antimicrob. Agents Chemother., 2016, 60, 2140-9. (link)



17. Masaoka, T.; Zhao, H.; Hirsch, D. R.; D'Erasmo, M. P.; Meck, C.; Varnado, B.; Gupta, A.; Meyers, M. J.; Baines, J. D.; Beutler, J. A.; Murelli, R. P.; Tang,L.; Le Grice, S. F. J. "Characterization the C-terminal nuclease domain of herpes simplex virus pUL15 as a target of nucleotidyltransferase inhibitors."Biochemistry, 2016, 55, 809-19. (link)



16. Zhao, H.; Lin, Z.; Lynn, A. Y.; Varnado, B.; Beutler, J. A.; Murelli, R. P.; Le Grice, S. F. J.; Tang, L. "Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism" Nucleic Acids Res. 2015, 43, 11003-16. (link)


15. Lu, G.; Lomonosova, E.; Cheng, X.; Moran, E. A.; Meyers, M. J.; Le Grice, S. F. J.; Thomas, C. J.; Jiang, J-K.; Meck, C.; Hirsch, D. R.; D'Erasemo, M. P.; Suyabatmaz, D. M.; Murelli, R. P.; Tavis, J. E. "Hydroxylated tropolones inhibit hepatitis B virus replication by blocking the viral ribonuclease H activity" Antimicrob. Agents Chemother. 2015, 59, 1070-1079. (link)


14. Hirsch, D. R.; Cox, G. C.; D'Erasmo, M. P.; Shakya, T.; Meck, C.; Mohd, N.; Wright, G. D.; Murelli, R. P. "Inhibition of ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones" Bioorg. Med. Chem. Lett. 2014, 24, 4943-4947. (link)



13. D'Erasmo, M. P.; Smith, W. B.; Munoz, A.; Mohandas, P.; Au, A. S.; Marineau, J.; Quadri, L. E. N.; Bradner, J. E.; Murelli, R. P. "7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-e-2-ones: Readily accessible and highly potent anticancer compounds" Bioorg. Med. Chem. Lett. 2014, 24, 4035-4038. (link)



12. Meck, C.; D' Erasmo, M. P.; Hirsch, D. R.; Murelli, R. P. "The biology and synthesis of α-hydroxytropolones" Med. Chem. Commun. 2014, 5, 842-852. (link)


11. Williams, Y. D.; Meck, C.; Mohd, N.; Murelli, R. P. "Triflic acid mediated rearrangements of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of methoxytropolones and furans" J. Org. Chem. 2013, 78, 11707-11713. (link)



10. Meck, C.; Mohd, N.; Murelli, R. P. "An oxidopyrylium cyclization/ ring-opening route to polysubstituted α-hydroxytropolones" Org. Lett. 2012, 14, 5988-5991. (link)



9. Munoz, A.; Murelli, R. P. "Acid-mediated coupling of gamma-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones" Tetrahedron Lett. 2012, 53, 6779-6781. (link)


Ryan's Postdoctoral Publications (Yale University)

8. Nelson, J. W.; Chammessian, A. G.; McEnaney, P. J.; Murelli, R. P.; Kazmiercak, B. I.; Spiegel, D. A. “A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-Native Small Molecules” ACS ChemBio, 2010, 5 , 1147-1155.(link)

See also: Cell, BioTechniques, Science Daily News and Yale Daily News

7. Zhang, A. X.; Murelli, R. P.; Barinka, C.; Michel, J.; Cocleaza, A.; Jorgensen, W. L.; Lubkowski, J.; Spiegel, D. A. “A Remote Arene Binding Site of Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules” J. Am. Chem. Soc. 2010, 132, 12711-12716.(link)

See also: Chemical & Engineering News Highlight and Nature ChemBio Highlight.

6. Murelli, R. P.; Zhang, A. X.; Michel, J.; Jorgensen, W. L.; Spiegel, D.A. “Chemical Control Over Immune Recognition:  A Class of Antibody-Recruiting Small Molecules (ARMs) that Target Prostate Cancer” J. Am. Chem. Soc. 2009, 131, 17090-17092.(link)

See also: ACS ChemBio Spotlight, ChemBioChem Highlight, Faculty of 1000 Biology Highlight, Drug Discovery News Article, Yale Daily News, and Science Daily News.

5. Stern, E.; Jay, S. M.; Demento, S. L.; Murelli, R. P.; Reed, M. A.; Malinski, T.; Spiegel, D. A.; Mooney, D. J.; Fahmy, T. M. “Spatiotemporal Control over Molecular Delivery and Cellular Encapsulation from Electropolymerized Micro and Nanopatterned Surfaces” Adv. Funct. Mater. 2009, 19, 2888-2895.(link)

Ryan's Graduate School Publications (Boston College)

4. Murelli, R. P.; Catalán, S.; Gannon, M. P.; Snapper, M. L. “Ruthenium-Catalyzed Enyne Cross-Metathesis-Cyclopropanation:  Three Component Access to Vinyl Cyclopropanes” Tetrahedron Lett., 2008, 49, 5714-5717.(link)

3. Murelli, R. P.; Snapper, M. L. “Ruthenium-Catalyzed Tandem Cross-Metathesis/ Wittig Olefination:  Generation of Conjugated Dienoic Esters from Terminal Olefins” Org. Lett. 2007, 9, 1749-1752.(link)

See also: Organic Chemistry Portal

2. Murelli, R. P.; Cheung, A. K.; Snapper, M. L. “Conformationally Restricted (+)-Cacospongionolide B Analogues:  Influence on Secretory Phospholipase A2 Inhibition” J. Org. Chem. 2007, 72, 1545-1552.(link)

See also: Journal Cover

1.  Cheung, A. K.; Murelli, R.; Snapper, M. L.  “Total Syntheses of (+)- and (-)-Cacospongionolide B,  Cacospongionolide E, and Related Analogues.  Preliminary Study of Structural Features Required for Phospholipase A2 Inhibition” J. Org. Chem. 2004, 69, 5712-5719.(link)

Patent Applications

3. Donlin, M. J.; Tavis, J. E.; Murelli, R.; Meyers, M. J. "Preparation of substituted cycloheptatrienones as antifungal compounds" PCT Int. Appli. No. WO 2017-184752. (Filed Oct. 2017).

2. Tavis, J. E; Morrison, L. A.; Murelli, R. P. "Preparation of hydroxylated tropolone inhibitorsof nucleotidyl transferases in treatment of herpesvirus and hepatitis B" PCT Int. Appl. No. WO 2016-201243. (Filed June 10, 2016)

1. Spiegel, D.; Murelli, R.; Zhang, A. “Chimeric Small Molecules that Recruit Antibodies to Cancer Cells” PCT Int. Appl. No. WO 2009-US2857.  Patent No. WO  2009139863. (Filed: Nov. 11, 2009).