Two publications have recently emerged from our group, both in the journal Medical Chemistry Communications. One of these papers describes Michael's proof-of-principle studies of a solid-phase adaptation to 7-Hydroxytropolone synthesis, whereas the other describes our studies of synthetic 7-hydroxytropolones as inhibitors of HIV RT RNaseH. Special thanks to the labs of Drs. Stuart Le Grice, John Beutler, and Emilio Gallicchio for making these studies possible.
Michael and Christine's paper on the discovery and development of a 3-component oxidopyrlium cycloaddition has recently been accepted to Journal of Organic Chemistry. Special thanks to Dr. Chad Lewis for his help throughout the process.
A series of publications have come out recently from our collaborative efforts on 7-hydroxytropolones. In the journal Antimicrobial Agents and Chemotherapeutics, Lynda Morrison of Saint Louis University School of Medicine describes the activity of synthetic 7-hydroxytropolones against herpes simplex virus. In a related study in the journal Biochemistry, Stuart Le Grice of the National Cancer Institute at Frederick describes how our library of 7-hydroxytropolones were used to help confirm new bioassays for a potential target for anti-HSV development, pUL15C. Finally, in the journal Nucleic Acids Research, Liang Tang of Kansas University describes the use of 7-hydroxytropolones to elucidate the mechanism of viral DNA-packaging terminase. These papers further highlight the growing interest in 7-hydroxytropolones and motivate our lab's synthetic chemistry efforts on this class of molecules.
Our efforts with the Tavis lab toward a therapeutically viable inhibitor of Hepatitis B RNaseH for use in curative medicine for chronic hepatitis B has been given a big boost with a grant from the National Institutes of Health. Read more about it here.
Ryan's postdoctoral research in the Spiegel lab on antibody-recruiting molecules for prostate cancer has led to a new worldwide licensing agreement between Yale University and Allied-Bristol Life Sciences (Allied Minds/Bristol-Myers Squibb). Read more about it here.
The group's very first PhD student, Christine Meck, has successfully defended her Thesis. Chrissy will be teaching at Elmira College next Fall, where she will be responsible for curriculum development. Congratulations Dr. Meck!
The group is awarded a grant from the National Institutes of Health (SC1GM111158) that will provide $1,558,600 to help fund the group's research over the next 4 years.
Sarah Avidan is selected as a recipient by the New York Local Section of the ACS for the William H. Nichols Fellowship Award. The fellowship will be used to support Sarah's research in the lab during the summer of 2015. Congratulations Sarah!
Danielle Hirsch is selected as a recipient of the WCC/Eli Lilly Travel Award to present her research at the Fall 2015 ACS National Meeting in Boston. Congratulations Danielle!
The group is honored to be selected as one of the recipients of the Alfred P. Sloan Foundation-Sponsored CUNY Junior Faculty Research Awards in Science and Engineering. The award will provide $50,000 to help fund our research over the next year. Read a writeup on Ryan and other winners of the award here.
One of our friends and collaborators, Dr. John Tavis, publishes a paper describing 7-hydroxytropolone's ability to inhibit hepatitis B viral replication through the inhibition of the viral RNaseH in Antimicrobial Agents and Chemotherapy. Congratulations Tavis lab and thanks for letting us be a part of these wonderful studies!
The group's manuscript describing the ability of synthetic 7-hydroxytropolones to inhibit mechanisms of aminoglycoside antibiotic resistance and restore antibiotic activity, authored by graduate students Michael D'Erasmo, Danielle Hirsch, Christine Meck and undergraduate student Noushad Mohd, is accepted for publication in Bioorganic and Medicinal Chemistry Letters. Thanks to the lab of Dr. Gerry Wright for all of your help!
The group's manuscript on the potent cytotoxicity of spirocyclic butenolides, authored by graduate student Michael D'Erasmo and undergraduate student Alberto Munoz, is accepted for publication in Bioorganic and Medicinal Chemistry Letters. Thanks to the labs of Drs. Luis Quadri and Jay Bradner for all of your help!
The group publishes the first ever review devoted to the biology and synthesis of 7-hydroxytropolones in Medicinal Chemistry Communications. We hope this will lead to greater interest in this exciting class of molecules.
The group's manuscript on a triflic acid-mediated rearrangments of oxidopyrylium-generated bicycles, authored by graduate research assistants Yvonne Williams, Christine Meck and undergraduate research assistant Noushad Mohd, is accepted for publication in Journal of Organic Chemistry
Christine Meck selected as a recipient of the WCC/Eli Lilly Travel Grant Award to present her research at the Fall 2013 ACS National Meeting in Indianapolis. Congratulations Chrissy!
Undergraduate Research Assistant Noushad Mohd wins second place prize for an essay he submitted for the 2012 CUNY Nobel Science Challenge. Congratulations Noushad!
The group's manuscript on a new method for the synthesis of 7-hydroxytropolones, authored by graduate research assistant Christine Meck and undergraduate research assistant Noushad Mohd, is accepted for publication in Organic Letters.
The group's manuscript on the synthesis of a new class of spirocyclic butenolides, authored by undergraduate Alberto Munoz, is accepted for publication in Tetrahedron Letters.
The group is awarded a grant from National Institutes of Health (SC2GM099596). The award will provide $471,000 to help fund the groups' research over the next 3 years.
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