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Ryan Murelli

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Brooklyn College Chemistry Department

Ph.D. in Chemistry at CUNY Graduate Center

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Group News

September 2018
PhD student Danielle Hirsch has successfully defended her thesis! In October, Danielle will be heading to MIT for a Postdoctoral Associate Position in Alison Wendlandt's group. Congrats Dr. Hirsch!

Dr. Danielle

August 2018
Our group has recently coauthored a manuscript in Antimicrobial Agents and Chemotherapeutics that describes our hydroxytropolones activity against Kaposi's sarcoma-associated herpesvirus. Thanks to Stuart Le Grice and his lab at the National Cancer Institute for letting us be a part of these studies!

July 2018
Our group has recently disclosed a final-step amidation strategy for hydroxytropolone diversification in Tetrahedron Letters. Congrats to Alex and Rudolf!

April 2018
We have recently published a review article on oxidopyrylium cycloaddition chemistry in Tetrahedron. Congrats Lauren!

March 2018
We recently coauthored a viewpoint on hepatitis B ribonyclease H inhibitor development with John Tavis, Grigoris Zoidis, and Marvin Meyers. You can read about it in ACS Infectious Diseases.

February 2018
Our ongoing collaborative studies on bioactive tropolones has led to another manuscript, this time out of the lab of Joel Baines of the LSU School of Veterinary Medicine. You can find the paper in Veterinary Microbiology. In the Baines group studies, it was found synthetic 7-hydroxytropolones can inhibit viral replication of cow, cat and horse-associated herpesviruses with structure-activity profiles comparable to human-associated HSV-1. Congrats to manuscript first author Shannon Dehghanpir of the Baines group!

January 2018
Michael's paper on fluorous phase synthesis of ╬▒HTs was accepted for publication in Journal of Organic Chemistry. Congrats Mike!

January 2018
Our group has had artwork chosen to be featured on the cover of Organic and Biomolecular Chemistry for the first issue of 2018, helping highlight our recent paper on the synthesis and biological evaluation of 3,7-dHTs. Thanks to Rajat and Danielle for their help putting this together.

December 2017
PhD student Michael D'Erasmo successfully defended his thesis, and in a month he will be moving on to Emory University to carry out postdoctoral research in the lab of Dennis Liotta. Congrats Dr. D'Erasmo, and do us proud!

November 2017
Our group's collaborative work with the Brenner-Moyer group at Rutgers-Newark on iminium activation-driven asymmetric oxidoprylium cycloaddition has recently been accepted to Organic Letters. Congrats to Niccole and Danielle!

November 2017
Our manuscript detailing the adaptation of our oxidopyrylium cycloaddion/ring-opening route to access 3,7-dihydroxytropolones, was recently accepted into Organic and Biomolecular Chemistry. This project, whose synthetic efforts were spearheaded by graduate student Danielle Hirsch, and supported by graduate students Dan Schiavone and Alex Berkowitz, also involved a heavy dose of biological, biochemical, and computational support from several of our collaborators. We thank the groups of John Tavis, Lynda Morrison, Stuart Le Grice, John Beutler, Liang Tang, and Emilio Gallicchio for their help on this project.

October 2017
Several papers have made their way into the literature recently stemming from our collaborative studies on the biological activity of our synthetic tropolones. Two of these came out of our NIH-funded project with the Tavis group, and represent important steps towards our goal of developing therapeuticaly viable anti-hepatitis B tropolones. The first publication, in Antiviral Research details our continued structure function studies, with a focus on cellular antiviral activity. The other manuscript, also in Antiviral Research, shows for the first time that inhibitors of hepatitis B's ribonuclease H activity, including one of our synthetic tropolones, can reduce the viral load in an animal model.

In addition, in a paper in Journal of Virology aimed at helping validate Herpes Simplex Virus UL12 as a target for antiviral development, the Weller lab at UConn recently found that several of our synthetic tropolones inhibited the enzyme. Excitingly, there was a close correlation between the structure function analysis determined by the Weller lab against UL12 and that determined in HSV-infected cells during the early phase of our ongoing collaboration with Lynda Morrison's lab at SLU.

March 2017
Graduate Student Danielle Hirsch was informed she will be awarded a Mina Rees Dissertation Fellowship in the Sciences for the 2017-2018 academic year. Congratulations Danielle!

February 2017
Maureen Donlin's studies on tropolone activity against Cryptococcus Neoformans, including an assessment of many of our synthetic 7-hydroxytropolones, was published in Antimicrobial Agents and Chemotherapeutics.

September 2016
A more detailed account of computational studies Emilio Gallicchio and his lab have been working on to study 7-hydroxytropolone inhibition of dinuclear metalloenzymes was published in ACS Omega.

July 2016
Two publications have recently emerged from our group, both in the journal Medical Chemistry Communications. One of these papers describes Michael's proof-of-principle studies of a solid-phase adaptation to 7-Hydroxytropolone synthesis, whereas the other describes our studies of synthetic 7-hydroxytropolones as inhibitors of HIV RT RNaseH. Special thanks to the labs of Drs. Stuart Le Grice, John Beutler, and Emilio Gallicchio for making these studies possible.

March 2016
Michael and Christine's paper on the discovery and development of a 3-component oxidopyrlium cycloaddition has recently been accepted to Journal of Organic Chemistry. Special thanks to Dr. Chad Lewis for his help throughout the process.

January 2016
A series of publications have come out recently from our collaborative efforts on 7-hydroxytropolones. In the journal Antimicrobial Agents and Chemotherapeutics, Lynda Morrison of Saint Louis University School of Medicine describes the activity of synthetic 7-hydroxytropolones against herpes simplex virus. In a related study in the journal Biochemistry, Stuart Le Grice of the National Cancer Institute at Frederick describes how our library of 7-hydroxytropolones were used to help confirm new bioassays for a potential target for anti-HSV development, pUL15C. Finally, in the journal Nucleic Acids Research, Liang Tang of Kansas University describes the use of 7-hydroxytropolones to elucidate the mechanism of viral DNA-packaging terminase. These papers further highlight the growing interest in 7-hydroxytropolones and motivate our lab's synthetic chemistry efforts on this class of molecules.

December 2015
Our efforts with the Tavis lab toward a therapeutically viable inhibitor of Hepatitis B RNaseH for use in curative medicine for chronic hepatitis B has been given a big boost with a grant from the National Institutes of Health. Read more about it here.

August 2015
Ryan's postdoctoral research in the Spiegel lab on antibody-recruiting molecules for prostate cancer has led to a new worldwide licensing agreement between Yale University and Allied-Bristol Life Sciences (Allied Minds/Bristol-Myers Squibb). Read more about it here.

June 2015
The group's very first PhD student, Christine Meck, has successfully defended her Thesis. Chrissy will be teaching at Elmira College next Fall, where she will be responsible for curriculum development. Congratulations Dr. Meck!

May 2015
The group is awarded a grant from the National Institutes of Health (SC1GM111158) that will provide $1,558,600 to help fund the group's research over the next 4 years.

April 2015
Sarah Avidan is selected as a recipient by the New York Local Section of the ACS for the William H. Nichols Fellowship Award. The fellowship will be used to support Sarah's research in the lab during the summer of 2015. Congratulations Sarah!

March 2015
Danielle Hirsch is selected as a recipient of the WCC/Eli Lilly Travel Award to present her research at the Fall 2015 ACS National Meeting in Boston. Congratulations Danielle!

February 2015
The group is honored to be selected as one of the recipients of the Alfred P. Sloan Foundation-Sponsored CUNY Junior Faculty Research Awards in Science and Engineering. The award will provide $50,000 to help fund our research over the next year. Read a writeup on Ryan and other winners of the award here.

December 2014
One of our friends and collaborators, Dr. John Tavis, publishes a paper describing 7-hydroxytropolone's ability to inhibit hepatitis B viral replication through the inhibition of the viral RNaseH in Antimicrobial Agents and Chemotherapy. Congratulations Tavis lab and thanks for letting us be a part of these wonderful studies!

September 2014
The group's manuscript describing the ability of synthetic 7-hydroxytropolones to inhibit mechanisms of aminoglycoside antibiotic resistance and restore antibiotic activity, authored by graduate students Michael D'Erasmo, Danielle Hirsch, Christine Meck and undergraduate student Noushad Mohd, is accepted for publication in Bioorganic and Medicinal Chemistry Letters. Thanks to the lab of Dr. Gerry Wright for all of your help!

May 2014
The group's manuscript on the potent cytotoxicity of spirocyclic butenolides, authored by graduate student Michael D'Erasmo and undergraduate student Alberto Munoz, is accepted for publication in Bioorganic and Medicinal Chemistry Letters. Thanks to the labs of Drs. Luis Quadri and Jay Bradner for all of your help!

March 2014
The group publishes the first ever review devoted to the biology and synthesis of 7-hydroxytropolones in Medicinal Chemistry Communications. We hope this will lead to greater interest in this exciting class of molecules.

October 2013
The group's manuscript on a triflic acid-mediated rearrangments of oxidopyrylium-generated bicycles, authored by graduate research assistants Yvonne Williams, Christine Meck and undergraduate research assistant Noushad Mohd, is accepted for publication in Journal of Organic Chemistry

April 2013
Christine Meck selected as a recipient of the WCC/Eli Lilly Travel Grant Award to present her research at the Fall 2013 ACS National Meeting in Indianapolis. Congratulations Chrissy!

February 2013
Undergraduate Research Assistant Noushad Mohd wins second place prize for an essay he submitted for the 2012 CUNY Nobel Science Challenge. Congratulations Noushad!

December 2012
The group's manuscript on a new method for the synthesis of 7-hydroxytropolones, authored by graduate research assistant Christine Meck and undergraduate research assistant Noushad Mohd, is accepted for publication in Organic Letters.

September 2012
The group's manuscript on the synthesis of a new class of spirocyclic butenolides, authored by undergraduate Alberto Munoz, is accepted for publication in Tetrahedron Letters.

September 2011
The group is awarded a grant from National Institutes of Health (SC2GM099596). The award will provide $471,000 to help fund the groups' research over the next 3 years.

January 2011
The Murelli research group is open for business.