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Ryan Murelli

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Course Information

Brooklyn College Chemistry Department

Ph.D. in Chemistry at CUNY Graduate Center

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Research Objectives

The Murelli Research Group is interested in the development of new synthetic methods that can be used to access and study small-molecules with known but underexplored biological activities.  Of particular interest to the lab are methods employing synthons derived from structural moieties found in nature, such as hydroxybutenolides and pyromeconic acid derivatives.  Research in the group will leverage the power of such synthetic methods for a range of purposes, including structure-activity relationship studies and the synthesis of molecular probes, all of which will provide insight into the mechanism of action of currently understudied biologically active small molecules. We are currently working on applying such synthons to target and study lead therapeutics for a host of diseases, including tuberculosis, HIV, cancer and heart disease.